Resistance of CAR-T Immunotherapy For Hematological Cancers
Now Watching Explore the advancements in CAR-T immunotherapy for relapsed/refractory B cell lymphomas and leukemia in an exclusive webcast featuring Dr. Marco Ruella, a distinguished expert in cellular immunotherapies. Dr. Ruella’s presentation will showcase innovative research focusing on enhancing CAR-T therapy by uncovering tumor evasion mechanisms and addressing challenges in CAR-T cell dysfunction and the […]
Automated Characterization Method for Validation of Epigenomic Editors in T Cells
Now Watchinghttps://youtu.be/-oRv-U2VMHg To view the transcript click here. Robust characterization methods are important analytical tools for phenotypic characterization in cell and gene therapy. For high-parameter flow cytometry methods, sample preparation is a highly complex and mostly manual procedure. Traditional flow cytometry methods are limited in throughput and resource intensive, which make them suboptimal for discovery screening […]
Getting to the Heart of the Matter: Novel Analytical Technologies Provide a New Perspective on a Complex Organ
Now Watchinghttps://www.youtube.com/watch?v=R-YT0iVN86c The heart is a 380-million-year-old organ, yet we do not have a complete understanding of the molecular landscape in the normal human adult heart. Of the many molecule classes present in the heart, we are especially lacking in our understanding of the cell surface proteins present on different cell types in the heart. […]
Critical Quality Metrics in Cell Sample Prep for Cell & Gene Therapy Bioanalytics
Now Watching In this panel discussion, Virginia Litwin, Ph.D. (CRL), Christoph Eberle, MICR, FRSPH (CRL), Mahwish Natalia, MA, Ph.D. (Takeda Oncology), and Melvin Lye, MBA (Curiox Biosystems) discuss the role of partnerships between early- and late-stream analytical assay developers. While tackling unique challenges in validating flow cytometric methods for Chimeric Antigen Receptor (CAR) T cells, […]
High-throughput antibody discovery to cell surface proteins
Now Watchinghttps://youtu.be/LJc8mh2qNpo Advances in the field of flow cytometry, particularly in the areas of plate-based sampling and high-throughput assays have greatly enabled antibody discovery processes. A major consideration with high-throughput flow cytometry has been the time and workflow for removing non-specific antibody binding to cells or protein coated beads by washing via centrifugation. No-wash flow-based […]
The First Generation AUTO 1000 Experience – Reasons to Believe
Now Watchinghttps://www.youtube.com/watch?v=diFhoIAebLg In this talk Cecilia Kwong shares her insights on the roadblocks of automating traditional sample preparation workflows and how she developed translational metrics for assay delivery with the Laminar Wash AUTO 1000 with a focus on: Identifying automation solutions fit for process Breakdown of translational metrics used Assessment and performance of the Laminar Wash […]
Overcoming challenges of Nuclei and Cell Preparation: A scientific perspective by S2 genomics and Curiox Story
Now Watchinghttps://youtu.be/inLymDAn4EI Single-cell transcriptome analysis has been extensively applied in humans and animal models to uncover gene expression heterogeneity between the different cell types of a tissue or an organ. Upstream processing may introduce inherent challenges that mask true analysis and increase user variability. Here we present a simple, yet combinatorial strategy from buffer and […]