Centrifuges expose suspension cells to large gravitational forces for extended periods of time. Laminar Wash technology is the first practical alternative to pelleting cells in tubes or 96-well plates using a centrifuge.
Centrifugation packs cells tightly together, often causing phenotypic changes that can bias data analysis.
Centrifugation also:
Pellets debris along with cells
Requires several manual steps prone to variation
Requires flinging or aspirating supernatants, which impacts reproducibility
Reduces cell retention and viability
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